Isaac married Margarette E. Darbyshire in 1861. Margarette was born on 7 Mar 1841 in Ohio, USA; died on 21 Feb 1887 in Clinton County, Ohio, USA; was buried in Sabina Cemetery, Sabina, Clinton County, Ohio, USA. [Group Sheet] [Family Chart]

Isaac married Anna T. Senne on 29 Aug 1891 in Clinton County, Ohio, USA, and was divorced. Anna (daughter of Karl August Senne and Magdalena Friedly) was born on 3 Oct 1863 in Franklin Township, Brown County, Ohio, USA; died in in Clinton County, Ohio, USA. [Group Sheet] [Family Chart]