Francis married Florence Margaret Epplin about 1942. Florence (daughter of Jacob Epplin and Theresa Mary Hoffman) was born on 18 May 1920 in Pinckneyville, Perry County, Illinois, USA; died on 15 Mar 2005 in Pinckneyville, Perry County, Illinois, USA. [Group Sheet] [Family Chart]

1. John Carl Eisfelder
2. Patricia Ann Eisfelder
3. Frances Marie Eisfelder
4. Rita Elizabeth Eisfelder
5. Margaret Theresa Eisfelder
6. Mary Jeanette Eisfelder