Isaac married Mary Elizabeth Schwartzmiller on 15 Dec 1859 in Seneca County, Ohio, USA. Mary (daughter of Georges Schwartzmüller Schwartzmiller and Catherine Frances Adelsperger) was born on 1 Aug 1839 in Tiffin, Seneca County, Ohio, USA; was christened on 18 Aug 1839 in St. Mary's Catholic Church, Tiffin, Seneca County, Ohio, USA; died on 3 Jun 1931 in Tiffin, Seneca County, Ohio, USA; was buried on 6 Jun 1931 in St. Mary's Catholic Cemetery, Tiffin, Seneca County, Ohio, USA. [Group Sheet] [Family Chart]

1. Catherine Huffman was born on 16 Dec 1861 in Seneca County, Ohio, USA; died on 2 Oct 1933 in Tiffin, Seneca County, Ohio, USA; was buried on 5 Oct 1933 in St. Mary's Catholic Cemetery, Tiffin, Seneca County, Ohio, USA.
2. George Huffman was born on 10 Jul 1865 in Seneca County, Ohio, USA; died on 9 Dec 1939 in Tiffin, Seneca County, Ohio, USA.
3. James Jacob Huffman was born on 12 Sep 1867 in Tiffin, Seneca County, Ohio, USA.
4. Martha Jane Huffman was born on 3 Mar 1870 in Seneca County, Ohio, USA; died on 27 Mar 1913 in Toledo, Lucas County, Ohio, USA.
5. Mary Idella Huffman was born on 19 Oct 1872 in Seneca County, Ohio, USA; died on 26 Oct 1949 in Seneca County, Ohio, USA; was buried in St. Andrew Catholic Cemetery, Bascom, Liberty Township, Seneca County, Ohio, USA.
6. Louis Edward Huffman was born on 10 May 1875 in Tiffin, Seneca County, Ohio, USA; died on 18 Mar 1908.
7. Alice Elizabeth Huffman was born on 19 Jun 1877 in Tiffin, Seneca County, Ohio, USA; died on 31 Oct 1937; was buried in Saint Wendelin Catholic Cemetery, Fostoria, Hancock County, Ohio, USA.
8. Emma Celestine Huffman was born on 15 Oct 1880 in Seneca County, Ohio, USA.